Overdosage Of Painkillers
Why Are Kidneys More Vulnerable?
- Drug Excretion: The kidneys remove drugs and their metabolites from the body, which can sometimes cause damage.
- High Blood Flow: The kidneys receive about 20% of the heart's blood flow, increasing exposure to harmful substances.
Drugs Commonly Causing Kidney Damage:
- Painkillers:
- NSAIDs (e.g., aspirin, ibuprofen) can damage kidneys, especially with long-term or high-dose use. Paracetamol is safer for kidney issues.
- Monitoring: Kidney damage from NSAIDs may be detected by protein in urine and elevated blood creatinine.
- Aminoglycosides:
- These antibiotics can cause kidney damage, particularly in high-risk patients. Preventive measures include cautious dosing, monitoring serum creatinine, and minimising risk factors.
- Radio-contrast Agents:
- Used in imaging tests, these can cause acute kidney failure, especially in high-risk patients. Prevention includes using minimal doses, non-ionic contrast, and maintaining hydration.
- Other Drugs:
- Certain antibiotics, anticancer drugs, and natural medicines (like some herbal supplements) can also damage kidneys, particularly those with heavy metals or high potassium content.
Prevention Tips:
- Avoid indiscriminate use of NSAIDs and other high-risk drugs.
- Ensure proper hydration and regular monitoring if using drugs known to affect kidney function.
